Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus. (December 2015)

• Record Type: Journal Article
• Authors: Nurjadi, D.; Schäfer, J.; Friedrich-Jänicke, B.; Mueller, A.; Neumayr, A.; Calvo-Cano, A.; Goorhuis, A.; Molhoek, N.; Lagler, H.; Kantele, A.; Van Genderen, P.J.J.; Gascon, J.; Grobusch, M.P.; Caumes, E.; Hatz, C.; Fleck, R.; Mockenhaupt, F.P.; Zanger, P.
• Is Part Of: Clinical microbiology and infection. Volume 21:Number 12(2015:Dec.)
• Page Start: 1095.e5
• Page End: 1095.e9
• Publication Date: 2015-12
• Subjects: Communicable diseases -- emerging drug resistance -- methicillin-resistant Staphylococcus aureus -- molecular epidemiology -- Panton–Valentine leukocidin -- sentinel surveillance -- staphylococcal skin infections -- travel -- trimethoprim–sulfamethoxazole combination; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2015.08.021
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: To investigate the global occurrence of trimethoprim–sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin and soft-tissue infections treated at 13 travel clinics in Europe. Thirty-eight per cent (75/196) were trimethoprim-resistant and 21% (41/196) were resistant to trimethoprim–sulfamethoxazole. Among methicillin-resistant S. aureus, these proportions were 30% (7/23) and 17% (4/23), respectively. DfrG explained 92% (69/75) of all trimethoprim resistance in S. aureus . Travel to South Asia was associated with the highest risk of acquiring trimethoprim–sulfamethoxazole-resistant S. aureus . We conclude that globally dfrG is the predominant determinant of trimethoprim resistance in human S. aureus infection.