HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients. (January 2015)

• Record Type: Journal Article
• Authors: Gianotti, N.; Canducci, F.; Galli, L.; Cossarini, F.; Salpietro, S.; Poli, A.; Nozza, S.; Spagnuolo, V.; Clementi, M.; Sampaolo, M.; Ceresola, E.R.; Racca, S.; Lazzarin, A.; Castagna, A.
• Is Part Of: Clinical microbiology and infection. Volume 21:Number 1(2015:Jan.)
• Page Start: 103.e7
• Page End: 103.e10
• Publication Date: 2015-01
• Subjects: HIV-1 DNA load -- kPCR -- residual viraemia -- virological failure -- virological rebound; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2014.08.004
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380–1930) copies/10 6 peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p 0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5–31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.