Shift in serotype distribution of Shigella species in China, 2003–2013. (March 2015)

• Record Type: Journal Article
• Authors: Qiu, S.; Xu, X.; Yang, C.; Wang, J.; Liang, B.; Li, P.; Li, H.; Yi, S.; Liu, H.; Cui, X.; Wu, Z.; Xie, J.; Jia, L.; Wang, L.; Hao, R.; Jin, H.; Wang, Y.; Sun, Y.; Song, H.
• Is Part Of: Clinical microbiology and infection. Volume 21:Number 3(2015:Mar.)
• Page Start: 252.e5
• Page End: 252.e8
• Publication Date: 2015-03
• Subjects: Atypical serotype -- serotype distribution -- shift -- Shigella -- vaccine development; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2014.10.019
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: We identified 2912 Shigella isolates from diarrhoeal patients in China during 2003–2013. The most common species was Shigella flexneri (55.3%), followed by Shigella sonnei (44.1%); however, S. sonnei is becoming increasingly prevalent. Among the S. flexneri isolates, serotypes 2a and X variant (-:7, 8, E1037) were the two most prevalent serotypes, and serologically atypical isolates were also commonly identified. Overall, S. sonnei, S. flexneri 2a and S. flexneri X variant (-:7, 8, E1037) accounted for 76.1% of all Shigella isolates, and their prevalence increased from 54.0% during 2003–2004 to 84.1% during 2011–2013. A change was observed in the serotype distribution of Shigella in China during this period, and we propose an ideal strategy to inform the development of a broadly effective Shigella vaccine candidate.