Spirulina maxima Protects Liver From Isoniazid and Rifampicin Drug Toxicity. (July 2014)

• Record Type: Journal Article
• Authors: Jatav, Santosh Kumar; Kulshrestha, Archana; Zacharia, Anish; Singh, Nita; Tejovathi, G.; Bisen, P. S.; Prasad, G. B. K. S.
• Is Part Of: Journal of evidence-based complementary & alternative medicine. Volume 19:Number 3(2014:Jul.)
• Page Start: 189
• Page End: 194
• Publication Date: 2014-07
• Subjects: tuberculosis -- hepatotoxicity -- isoniazid -- rifampicin -- Spirulina maxima; Alternative medicine -- Periodicals; Complementary Therapies -- Periodicals; 615.505
• DOI: 10.1177/2156587214530720
• Languages: English
• ISSNs: 2156-5872

Abstract

Hepatotoxicity associated with isoniazid and rifampicin is one of the major impediments in antituberculosis therapy. The present study explored the prophylactic and therapeutic efficacies of Spirulina maxima in isoniazid and rifampicin induced hepatic damage in a rat model. Hepatic damage induced in Wistar rats by isoniazid and rifampicin resulted in significant alterations in biomarkers of liver function, namely, bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, and oxidative stress markers such as superoxide dismutase, catalase, glutathione, and thiobarbituric acid reactive substances. Co-administration of Spirulina maxima along with antituberculosis drugs protected liver from hepatotoxicity due to isoniazid and rifampicin. Administration of Spirulina maxima consecutively for 2 weeks to hepatodamaged animals resulted in restoration of hepatic function as evident from normalization of serum markers of liver function. Thus, the present study revealed remarkable prophylactic and therapeutic potential of Spirulina maxima . Co-administration of Spirulina maxima and antituberculosis drugs is advantageous as it provides extra nutritional benefit.