Strong and persistent correlation between baseline and follow-up HIV-DNA levels and residual viremia in a population of naïve patients with more than 4 years of effective antiretroviral therapy. (March 2015)

• Record Type: Journal Article
• Authors: Parisi, S.G.; Sarmati, L.; Andreis, S.; Scaggiante, R.; Cruciani, M.; Ferretto, R.; Manfrin, V.; Basso, M.; Andreoni, M.; Mengoli, C.; Palù, G.
• Is Part Of: Clinical microbiology and infection. Volume 21:Number 3(2015:Mar.)
• Page Start: 288.e5
• Page End: 288.e7
• Publication Date: 2015-03
• Subjects: Cellular HIV-DNA -- HIV-RNA -- naïve patients -- primary infection -- residual viremia; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2014.10.009
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: In a longitudinal study on 181 naïve patients who responded to therapy (mean follow-up 4 years), high baseline human immunodeficiency virus (HIV)-RNA values correlated with high levels of cellular HIV-DNA at all time points (p < 0.0001, p 0.045, p 0.0055, and p 0.0025, respectively) and negatively correlated with undetectable residual viremia (URV; <2.5 copies/mL) at T1, T2, and T3 (p 0.026, p 0.0149, and p 0.0002, respectively). Baseline high HIV-DNA levels predicted the persistence of high values (p 0.0001) and negatively correlated with URV (p 0.0254, p 0.0481, and p 0.0085). These results suggest that baseline viral load, cellular HIV-DNA, and URV were strongly correlated over long-term follow-up of antiretroviral therapy responders.