Bone marrow CD34+ progenitor cells may harbour HIV-DNA even in successfully treated patients. (March 2015)

• Record Type: Journal Article
• Authors: Bordoni, V.; Bibas, M.; Abbate, I.; Viola, D.; Rozera, G.; Agrati, C.; Rinaldi, A.; Amendola, A.; Ammassari, A.; Capobianchi, M.R.; Martini, F.
• Is Part Of: Clinical microbiology and infection. Volume 21:Number 3(2015:Mar.)
• Page Start: 290.e5
• Page End: 290.e8
• Publication Date: 2015-03
• Subjects: Bone marrow -- hematopoietic progenitor cells -- HIV infection -- proviral DNA -- viral load; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2014.11.003
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: The issue about bone marrow hematopoietic progenitor cells harbouring HIV-DNA in infected patients is still under scrutiny. We studied nine HIV-infected individuals undergoing bone marrow aspiration for diagnostic purposes. In all patients, even in those receiving successful antiretroviral therapy for several years, HIV-DNA was detected in purified CD34+ lineage-bone marrow progenitor cells. This finding, although not conclusive due to the low number of patients examined, adds further evidence that current treatment strategies may be insufficient to resolve latent infection in bone marrow CD34+ hematopoietic progenitor cells.