IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals. (March 2015)

• Record Type: Journal Article
• Authors: Machmach, K.; Abad-Molina, C.; Romero-Sánchez, M.C.; Dominguez-Molina, B.; Moyano, M.; Rodriguez, M.M.; Rafii-El-Idrissi Benhnia, M.; Jimenez-Mejias, M.E.; Vidal, F.; Muñoz-Fernández, M.A.; Genebat, M.; Viciana, P.; González-Escribano, M.F.; Leal, M.; Ruiz-Mateos, E.
• Is Part Of: Clinical microbiology and infection. Volume 21:Number 3(2015:Mar.)
• Page Start: 289.e1
• Page End: 289.e4
• Publication Date: 2015-03
• Subjects: HIV infection -- AIDS -- CD4 -- IFNL4 -- IL28B; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2014.10.012
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: The IFNL4 ss469415590 polymorphism, in high linkage disequilibrium with the IL28B rs12979860 variant, has been associated with hepatitis C virus clearance. We evaluated whether ss469415590 is associated with clinical and immunovirological parameters in human immunodeficiency virus-infected subjects. We found an independent association of the IFNL4 ss469415590 polymorphism with higher prevalence of AIDS-defining illnesses and lower CD4 T cell numbers. These results suggest the existence of common host defence mechanisms against different viral infections.