Extracorporeal photopheresis for the treatment of Crohn's disease. Issue 2 (April 2015)

• Record Type: Journal Article
• Authors: Fowler, Sharyle; Jones, Jennifer; Hull, Peter R.; Ghosh, Subrata
• Is Part Of: Transfusion and apheresis science. Volume 52:Issue 2(2015)
• Page Start: 183
• Page End: 186
• Publication Date: 2015-04
• Subjects: Blood -- Transfusion -- Periodicals; Hemapheresis -- Periodicals; 615.39
• DOI: 10.1016/j.transci.2015.02.006
• Languages: English
• ISSNs: 1473-0502

Abstract

Abstract: Small, open-label studies show promising results for ECP in the treatment of steroid-dependent and medically-refractory Crohn's disease. However, proper randomized, sham-controlled trials have not yet been performed. Based on the proposed mechanism of action of ECP, induction of a tolerogenic T cell response, ECP should be assessed in patients with early inflammatory disease rather than those who have progressed to fibrotic or stricturing disease. Randomized, sham-controlled trials need to be performed before ECP can be incorporated into standard clinical practice for the treatment of Crohn's disease.