Is admission screening for Pseudomonas aeruginosa useful in haematologic patients? A prospective study with 1310 patients. (June 2015)

• Record Type: Journal Article
• Authors: Sidler, J.A.; Frei, R.; Tschudin-Sutter, S.; Dangel, M.; Battegay, M.; Weisser, M.; Passweg, J.; Widmer, A.F.
• Is Part Of: Clinical microbiology and infection. Volume 21:Number 6(2015:Jun.)
• Page Start: 572.e1
• Page End: 572.e3
• Publication Date: 2015-06
• Subjects: Bloodstream infection -- colonization -- molecular typing -- Pseudomonas aeruginosa -- screening; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2015.02.004
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: Screening for Pseudomonas aeruginosa is recommended to guide empirical antimicrobial therapy in patients on high-risk units. However, evidence for this approach is scarce. We therefore screened 1310 patients with severe haematologic diseases for P. aeruginosa colonization at admission: 108 (8.2%) were positive, but only nine (0.7%; six with the same clone as in the screening isolate) subsequently developed a P. aeruginosa bloodstream infection (positive predictive value of screening, 8.6%; negative predictive value of screening, 99.5%). Routine screening for P. aeruginosa at admission did not sufficiently predict subsequent bloodstream infections caused by P. aeruginosa.