Fullerene up-take alters bilayer structure and elasticity: A small angle X-ray study. (May 2015)

• Record Type: Journal Article
• Authors: Drasler, Barbara; Drobne, Damjana; Sadeghpour, Amin; Rappolt, Michael
• Is Part Of: Chemistry and physics of lipids. Volume 188(2015)
• Page Start: 46
• Page End: 53
• Publication Date: 2015-05
• Subjects: Fullerene -- Toxicity -- POPC -- Bilayer structure -- Membrane undulations -- SAXS; Lipids -- Periodicals; Lipids -- Periodicals; Lipides -- Périodiques; Lipids; Periodicals; Electronic journals; 547.77
• DOI: 10.1016/j.chemphyslip.2015.04.001
• Languages: English
• ISSNs: 0009-3084

Abstract

Graphical abstract: Highlights: Exposure to fullerenes (C60 ) can lead to damaging effects on biomembranes. C60 causes increase in the bilayer undulations (∼20%). C60 enhances the mean inter-bilayer separation (∼15%). C60 -incorporation increased the linear expansion coefficient. Addition of C60 causes a drop in the bending rigidity of the bilayers (20–40%). Abstract: The coupling of fullerene (C60 ) to the structure and elasticity of 1-palmitoyl-2-oleoyl- sn -glycero-3-phosphocholine bilayers has been explored by synchrotron small angle X-ray scattering. Multilamellar vesicles were loaded with 0, 2 and 10 mol.% of C60 and studied in a temperature range from 15 to 65 °C. The addition of C60 caused an increase in the bilayer undulations (∼20%), in the bilayer separation (∼15%), in the linear expansion coefficient and caused a drop in the bending rigidity of the bilayers (20–40%). Possible damaging effects of fullerene on biomembranes are mainly discussed on the basis of altered bilayer fluidity and elasticity changes.