The influence of steatosis on the short- and long-term results of resection of liver metastases from colorectal carcinoma. Issue 4 (April 2016)

• Record Type: Journal Article
• Authors: Ramos, Emilio; Torras, Jaume; Lladó, Laura; Rafecas, Antoni; Serrano, Teresa; Lopez-Gordo, Sandra; Busquets, Juli; Fabregat, Joan
• Is Part Of: HPB. Volume 18:Issue 4(2016)
• Page Start: 389
• Page End: 396
• Publication Date: 2016-04
• Subjects: Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 616.362005
• DOI: 10.1016/j.hpb.2015.12.002
• Languages: English
• ISSNs: 1365-182X

Abstract

Abstract: We aimed to establish whether the presence of hepatic steatosis influences outcome after resection of colorectal liver metastases (CLM). Patients and methods: Patients operated between 1990 and 2014 were divided into four groups based on the degree of hepatic steatosis. The association between hepatic steatosis and outcome was analyzed, using a multivariate and a propensity score case-match analysis. Results: No significant differences were observed between patients with and without steatosis in either mortality or morbidity in the complete series or after matching (3.2% vs. 3.5%/p = 0.845) (32.3% vs 31.4%/p = 0.802). Five-year survival in patients with and without steatosis were 56.5% and 46.5% respectively (p = 0.046). The steatosis had a significant protective effect in the univariate analysis (HR (95% CI) = 0.78 (0.62–0.99) p = 0.048), and was close to significance in the multivariate analysis (HR (95%) = 0.81 (0.63–1.03) p = 0.089). No significant differences were seen with regard to liver recurrence. Conclusions: The presence of steatosis does not predict short-outcome after resection of CLM, but appears to be a favorable prognostic factor for survival. This protective effect does not depend on a decrease in liver recurrence.