Concurrent interspecies and clonal dissemination of OXA-48 carbapenemase. (February 2015)

• Record Type: Journal Article
• Authors: Arana, D.M.; Saez, D.; García-Hierro, P.; Bautista, V.; Fernández-Romero, S.; Ángel de la Cal, M.; Alós, J.I.; Oteo, J.
• Is Part Of: Clinical microbiology and infection. Volume 21:Number 2(2015:Feb.)
• Page Start: 148.e1
• Page End: 148.e4
• Publication Date: 2015-02
• Subjects: Carbapenemase -- interspecies dissemination -- OXA-48 -- ST15 -- Klebsiella pneumoniae; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2014.07.008
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: Several isolates of four different carbapenemase-producing Enterobacteriaceae species were recovered from a patient hospitalized for 4 months in a teaching hospital in Madrid. These species comprised seven Klebsiella pneumoniae belonging to ST15, four Escherichia coli belonging to ST2531, two Serratia marcescens and one Citrobacter freundii . This patient was the index case of a small outbreak of four patients infected and/or colonized by carbapenemase-producing K. pneumoniae . Molecular results identified the bla OXA-48 gene in all Enterobacteriaceae isolates from the index case and in all isolates from the other three patients, suggesting intra- and interpatient dissemination. Our results highlight the great ability of OXA-48 carbapenemase to spread among different enterobacterial species by both clonal and nonclonal dissemination.