Heart transplantation as salvage treatment of intractable infective endocarditis. (April 2015)

• Record Type: Journal Article
• Authors: Aymami, Marie; Revest, Matthieu; Piau, Caroline; Chabanne, Céline; Le Gall, François; Lelong, Bernard; Verhoye, Jean-Philippe; Michelet, Christian; Tattevin, Pierre; Flécher, Erwan
• Is Part Of: Clinical microbiology and infection. Volume 21:Number 4(2015:Apr.)
• Page Start: 371.e1
• Page End: 371.e4
• Publication Date: 2015-04
• Subjects: Heart transplantation -- infective endocarditis -- intracardiac fistula -- periannular abscesses -- salvage treatment; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2014.11.027
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: This study reports six consecutive patients who underwent heart transplantation as salvage treatment for endocarditis (Duke criteria) with extensive perivalvular lesions and end-stage heart failure. The median age was 45 years (range, 24 to 64), and the aortic valve was affected in all patients. Pathogens were Staphylococcus aureus (n = 2), Streptococcus pneumoniae (n = 2), Streptococcus agalactiae (n = 1), or not documented (n = 1). All patients survived, with no relapse, after a median follow-up of 24.5 months. The 10 patients with heart transplantation for endocarditis previously reported also survived (median follow-up, 27.5 months). Heart transplantation may be considered as salvage treatment in selected patients with intractable infective endocarditis.