Plasma levels of haemostatic factors in patients with pulmonary embolism on admission and seven months later. (4th September 2017)

• Record Type: Journal Article
• Authors: Sane, M.; Granér, M.; Laukkanen, J. A.; Harjola, V.‐P.; Mustonen, P.
• Is Part Of: International journal of laboratory hematology. Volume 40:Number 1(2018:Feb.)
• Page Start: 66
• Page End: 71
• Publication Date: 2017-09-04
• Subjects: coagulation -- coagulation factors -- factor XIII -- pulmonary embolism -- venous thrombosis; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; 616.15005
• DOI: 10.1111/ijlh.12729
• Languages: English
• ISSNs: 1751-5521

Abstract

Abstract: Introduction: With the exception of D‐dimer, not much is known about the plasma levels of haemostatic factors during acute venous thromboembolism (VTE) compared to their basic levels in a stable phase. The goal of this study was to examine how plasma levels of factor V, VIII, XIIIa, von Willebrand factor antigen (vWF:Ag), fibrinogen, thrombomodulin evolve from the point of diagnosis of acute VTE to the end of standard treatment period. Methods: Sixty‐three consecutive patients (mean 57, range 18‐86 years, 33 females) with acute pulmonary embolism (PE) were included. Laboratory samples were collected upon arrival (acute phase) and seven months later (stable phase). Fifteen similar aged individuals served as controls. Results: Plasma levels of factor XIIIa (87.5% vs 117.7%, P < .001) and soluble thrombomodulin (36.6 vs 47.5 ng/L, P < .001) were lower, whereas plasma levels of vWF:Ag (2.66 vs 2.01 IU/mL, P < .001) and fibrinogen (4.3 vs 3.9 g/L, P < .05) were higher on admission compared to the stable phase. In the stable phase, vWF:Ag (2.01 vs 1.43 IU/mL, P < .01) and soluble thrombomodulin (47.5 vs 38.0 ng/mL, P < .05), but not FXIIIa levels, were higher in PE patients compared to healthy controls. Conclusion: This study confirms the concept of FXIIIa consumption during acute phase of VTE by showing its intraindividual normalization during the follow‐up. vWF:Ag, known to be associated with the risk of VTE, was constantly elevated in the majority of the patients. Soluble thrombomodulin levels were lower in acute phase compared to stable phase, a finding which significance needs to be evaluated in the future.