Ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by inhibition of drug resistance. Issue 1 (18th November 2017)

• Record Type: Journal Article
• Authors: Zhang, Ye; Huang, Longchang; Shi, Haoze; Chen, Hang; Tao, Jianxin; Shen, Renhui; Wang, Tong
• Is Part Of: Cancer science. Volume 109:Issue 1(2018)
• Page Start: 94
• Page End: 102
• Publication Date: 2017-11-18
• Subjects: colorectal cancer -- drug resistance -- proliferation -- reactive oxygen species -- ursolic acid; Cancer -- Periodicals; Neoplasms -- Periodicals; Research -- Periodicals; Electronic journals; 616.994005
• DOI: 10.1111/cas.13425
• Languages: English
• ISSNs: 1347-9032

Abstract

Abstract : It has been reported that ursolic acid has anti‐tumor activity and it enhances the therapeutic effect of oxaliplatin in colorectal cancer (CRC). However, the underlying mechanisms remain unknown. In the present study, the mechanisms of the enhancement of therapeutic effects through use of ursolic acid were investigated. We treated CRC cell lines HCT8 and SW480 with ursolic acid and oxaliplatin and monitored the effects on cell proliferation, apoptosis, reactive oxygen species (ROS) production and drug resistance gene production. We discovered that treatment with a combination of ursolic acid and oxaliplatin resulted in significant inhibition of cell proliferation, significantly increased apoptosis and ROS production, and significant inhibition of drug resistance gene expression. Our study provided evidence that ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by ROS‐mediated inhibition of drug resistance. Abstract : Our study showed that ursolic acid enhanced the therapeutic effects of oxaliplatin. Ursolic acid and oxaliplatin treatment resulted in increased inhibition of proliferation and increased apoptosis in CRC cells. These pheromones were correlated with significantly increased ROS production and decreased expression of drug resistance gene P‐gp, MRP and BCRP.