Interfering with DNA High‐Order Structures using Chiral Ruthenium(II) Complexes. Issue 3 (6th December 2017)

• Record Type: Journal Article
• Authors: Zou, Shanshan; Li, Guanying; Rees, Thomas W.; Jin, Chengzhi; Huang, Juanjuan; Chen, Yu; Ji, Liangnian; Chao, Hui
• Is Part Of: Chemistry. Volume 24:Issue 3(2018)
• Page Start: 690
• Page End: 698
• Publication Date: 2017-12-06
• Subjects: chirality -- DNA -- high-order structures -- planarity -- ruthenium; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201704403
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: In this work, it was found that DNA can undergo B‐Z transformational changes and compaction in the presence of DNA intercalators such as ruthenium(II) polypyridyl complexes. The link between B‐Z transition and condensation is weak but can be strengthened under certain circumstances with slight alterations to the structures of the ruthenium(II) complexes. Here, following on from previous research, this work reports a series of ruthenium(II) complexes with imidazophenanthroline ligands, which vary in size and planarity. The complexes exhibit distinct effects on DNA structures, ranging from little impact to the transformation of DNA secondary structures to the formation of higher‐order DNA structures. Further studies on DNA morphological changes induced by chiral ruthenium(II) complexes are observed by atomic force microscopy and transmission electron microscopy. Abstract : High‐order structures : The structural effects of a series of chiral polypyridyl Ru II complexes on DNA high‐order structures are studied by spectral and morphological tools (see figure). The distinct effects on DNA are closely linked to the increasing aromatic conjuction area of the main ligands.