Modeling phenotypes of malignant gliomas. Issue 1 (15th November 2017)

• Record Type: Journal Article
• Authors: Sampetrean, Oltea; Saya, Hideyuki
• Is Part Of: Cancer science. Volume 109:Issue 1(2018)
• Page Start: 6
• Page End: 14
• Publication Date: 2017-11-15
• Subjects: experimental model -- genetically engineered mouse model -- glioma cell of origin -- glioma invasion -- malignant glioma; Cancer -- Periodicals; Neoplasms -- Periodicals; Research -- Periodicals; Electronic journals; 616.994005
• DOI: 10.1111/cas.13351
• Languages: English
• ISSNs: 1347-9032

Abstract

Abstract: Malignant gliomas are primary tumors of the central nervous system characterized by diffuse infiltration into the brain and a high recurrence rate. Advances in comprehensive genomic studies have provided unprecedented insight into the genetic and molecular heterogeneity of these tumors and refined our understanding of their evolution from low to high grade. However, similar levels of phenotypic characterization are indispensable to understanding the complexity of malignant gliomas. Experimental glioma models have also achieved great progress in recent years. Advances in transgenic technologies and cell culture have allowed the establishment of mouse models that mirror the human disease with increasing fidelity and which support single‐cell resolution for phenotypic analyses. Here we review the major types of preclinical glioma models, with an emphasis on how recent developments in experimental modeling have shed new light on two fundamental aspects of glioma phenotype, their cell of origin and their invasive potential. Abstract : In the present article we review the major types of preclinical glioma models, with an emphasis on the latest technical advances, and outline the latest findings regarding two defining aspects of glioma biology: the cell of origin and tumor cell invasion.