Acute painful autoimmune neuropathy: A variant of Guillain‐Barré syndrome. Issue 2 (24th July 2017)

• Record Type: Journal Article
• Authors: Yuki, Nobuhiro; Chan, Amanda C.; Wong, Anna Hiu Yi; Inoue, Takayuki; Yokai, Masafumi; Kurihara, Takashi; Devaux, JérôMe J.; Wilder‐Smith, Einar
• Is Part Of: Muscle & nerve. Volume 57:Issue 2(2018)
• Page Start: 320
• Page End: 324
• Publication Date: 2017-07-24
• Subjects: acute onset -- Guillain‐Barré syndrome -- neuropathic pain -- sensory neuropathy -- small‐fiber neuropathy; Neuromuscular diseases -- Periodicals; Muscles -- Periodicals; Nerves -- Periodicals; 616.74
• DOI: 10.1002/mus.25738
• Languages: English
• ISSNs: 0148-639X

Abstract

ABSTRACT: Introduction: We present a painful small‐fiber neuropathy variant of Guillain‐Barré syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation. Methods: Two patients received intravenous immunoglobulin, one corticosteroids. Results: The patients subsequently improved. Immunoglobulin G (IgG) antibodies in their acute phase sera strongly bound to murine small nerve fibers, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses. Discussion: Our case series suggest that an acute transient immune response can be directed against small nerve fibers, and that patients so affected can exhibit features of Guillain‐Barré syndrome. Muscle Nerve 57 : 320–324, 2018