Preparation of stimuli-responsive nanogels based on poly(N, N-diethylaminoethyl methacrylate) by a simple "surfactant-free" methodology. Issue 1 (2nd January 2018)

• Record Type: Journal Article
• Authors: Manzanares-Guevara, Lizbeth A; Licea-Claverie, Angel; Paraguay-Delgado, Francisco
• Is Part Of: Soft materials. Volume 16:Issue 1(2018)
• Page Start: 37
• Page End: 50
• Publication Date: 2018-01-02
• Subjects: Environment sensitive polymers -- gold nanoparticles -- nanogels -- polyethyleneglycol -- surfactant free emulsion; Materials science -- Periodicals; 620.11
• DOI: 10.1080/1539445X.2017.1391845
• Languages: English
• ISSNs: 1539-445X

Abstract

ABSTRACT: The synthesis of poly(N, N-diethylaminoethyl methacrylate)-core-polyethyleneglycol-shell (PDEAEM-core-PEG-shell) nanogels was achieved by using a "surfactant-free" emulsion polymerization with the aid of commercially available polyethyleneglycol methyl ether methacrylates (PEGMAs) as polymerizable stabilizers. By adjusting the synthetic parameters like the choice of initiator, cross-linker, PEGMA:DEAEM ratio, and molecular weight of PEGMA, a series of core-shell nanogels varying in size (50–350 nm), PDEAEM content, and pH/temperature responsive behavior were obtained in reactions taking only 60 min. The nanogels were used as nanoreactors for the preparation of gold nanoparticles. The PEGylated nanogels have a great potential to be used for diagnosis and therapy.