The effect of anthracene-based chalcone derivatives in the resazurin dye reduction assay mechanisms for the investigation of Gram-positive and Gram-negative bacterial and fungal infection. (15th December 2017)

• Record Type: Journal Article
• Authors: Prakash, Gopi; Boopathy, Mani; Selvam, Ramasamy; Johnsanthosh Kumar, Samuel; Subramanian, Kathavarayan
• Is Part Of: New journal of chemistry. Volume 42:Number 2(2018)
• Page Start: 1037
• Page End: 1045
• Publication Date: 2017-12-15
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj04125j
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A novel series of anthracene-based chalcone derivatives were synthesized and evaluated in terms of their antibacterial and antifungal activities. Abstract : A novel series of anthracene-based chalcone derivatives (ANNP, ANMNP, ANFL, ANAT, ANID, ANPT andANTP ) containing naphthalene, 6-methoxy naphthalene, fluorene, anthracene, indole, phenothiazine and thiophene were synthesized and evaluated in terms of their antibacterial and antifungal activities. Most of the synthesized compounds showed potent inhibitory activity towards various bacteria and fungi with minimum inhibitory concentrations (MICs) ranging from 0.39 to 100 μg mL −1 . Their antibacterial and antifungal activities have been evaluated using a resazurin dye reduction assay method. These compounds showed moderate to good antibacterial and antifungal activities. CompoundsANNP, ANFL, ANID andANPT were found to be the most potent with an MIC value of 3.12 (μg mL −1 ) against bacterial strains Bacillus cereus and Staphylococcus aureus . CompoundsANFL andANAT also exhibited the same inhibitory activity with a MIC value of 3.12 (μg mL −1 ) against the fungal strains Candida albicans and Candida cruzi while the remaining compounds showed moderate to weak activities as compared to the corresponding standard drugs.