Bioactive bredigite coating with improved bonding strength, rapid apatite mineralization and excellent cytocompatibility. (May 2014)

• Record Type: Journal Article
• Authors: Yi, Deliang; Wu, Chengtie; Ma, Bing; Ji, Heng; Zheng, Xuebin; Chang, Jiang
• Is Part Of: Journal of biomaterials applications. Volume 28:Number 9(2014:May)
• Page Start: 1343
• Page End: 1353
• Publication Date: 2014-05
• Subjects: Plasma spraying -- bredigite coating -- bonding strength -- simulated body fluid -- bone marrow stem cells; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1177/0885328213508165
• Languages: English
• ISSNs: 0885-3282

Abstract

Previous studies have shown that bredigite (Ca7 MgSi4 O16 ) bioceramics possessed excellent biocompatibility, apatite-mineralization ability and mechanical properties. In this paper, the bredigite coating on Ti-6Al-4 V substrate was prepared by plasma spraying technique. The main compositions of the coating were bredigite crystal phase with small parts of amorphous phases. The bonding strength of the coating to Ti-6Al-4 V substrate reached 49.8 MPa, which was significantly higher than that of hydroxyapatite coating and other silicate-based bioceramic coatings prepared by same method. After immersed in simulated body fluid for 2 days, a distinct apatite layer was deposited on the surface of bredigite coating, indicating that the prepared bredigite coating has excellent apatite-mineralization ability. The prepared bredigite coating supported the attachment and proliferation of rabbit bone marrow stem cells. The proliferation level of bone marrow stem cells was significantly higher than that on the hydroxyapatite coating. Our further study showed that the released SiO4 4– and Mg 2+ ions from bredigite coating as well as the formed nano-apatite layer on the coating surface might mainly contribute to the improvement of cell proliferation. The results indicated that the bredigite coating may be applied on orthopedic implants due to its excellent bonding strength, apatite mineralization and cytocompatibility.