Genetic and ethnic modulation of cardiovascular toxicity of vascular endothelial growth factor inhibitors. (2nd January 2018)

• Record Type: Journal Article
• Authors: Chen, Yen-Chou; Chung, Cheng-Chih; Lin, Yung-Kuo; Chen, Yi-Jen
• Is Part Of: Annals of medicine. Volume 50:Number 1(2018)
• Page Start: 46
• Page End: 56
• Publication Date: 2018-01-02
• Subjects: Angiogenesis inhibitors -- antibodies -- cardiovascular system -- cardiotoxicity -- ethnic groups -- tyrosine kinase inhibitors -- vascular endothelial growth factors; Medicine -- Periodicals; 610
• DOI: 10.1080/07853890.2017.1383629
• Languages: English
• ISSNs: 0785-3890

Abstract

Abstract: Vascular endothelial growth factor (VEGF) inhibitors, including monoclonal antibodies and tyrosine kinase inhibitors (TKIs), are important as anticancer treatments through curbing tumour angiogenesis and growth. VEGF inhibitors have significant cardiovascular effects. By blocking VEGF receptors, ligands, or signal pathways, VEGF inhibitors disturb the balance between vasodilation and vasoconstriction, undermine endothelial cell integrity, and activate cardiomyocyte apoptosis. VEGF inhibitors increase risks of hypertension, heart failure, thromboembolism and arrhythmia. Genetic and geographic studies showed that genetic polymorphisms likely play significant predictive or prognostic roles in cardiovascular toxicity associated with VEGF inhibitors. This review updates current understandings of VEGF inhibitors on cardiovascular toxicity, explores potential mechanisms, and clarifies whether genetic or ethnic factors contribute to their adverse effects. Key Messages: VEGF inhibitors disturb the balance between vasodilation and vasoconstriction, undermine endothelial cell integrity and activate cardiomyocyte apoptosis. VEGF inhibitors increase risks of hypertension, heart failure, thromboembolism and arrhythmia. Genetic and geographic studies showed that genetic polymorphisms likely play significant predictive or prognostic roles in cardiovascular toxicity associated with VEGF inhibitors.