Catalyst- and solvent-free bisphosphinylation of isothiocyanates: a practical method for the synthesis of bisphosphinoylaminomethanes. Issue 1 (7th December 2017)

• Record Type: Journal Article
• Authors: Wen, Li-Rong; Sun, Yong-Xu; Zhang, Jin-Wei; Guo, Wei-Si; Li, Ming
• Is Part Of: Green chemistry. Volume 20:Issue 1(2018)
• Page Start: 125
• Page End: 129
• Publication Date: 2017-12-07
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c7gc03101g
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A new protocol for the construction of bisphosphinoylaminomethanes was developed through double addition of phosphine oxides to isothiocyanates. Abstract : A general and convenient double addition of phosphine oxides to isothiocyanates is described. It is a practically useful protocol for the construction of bisphosphinoylaminomethanes. The reaction can be carried out smoothly under metal- and solvent-free conditions. It also features a broad substrate scope, simple operation and purification. A possible mechanism involving a tandem double nucleophilic addition/H2 S elimination/ in situ imine reduction process is proposed.