Selective targeting of PARP-1 zinc finger recognition domains with Au(iii) organometallics. Issue 6 (2nd January 2018)

• Record Type: Journal Article
• Authors: Wenzel, Margot N.; Meier-Menches, Samuel M.; Williams, Thomas L.; Rämisch, Eberard; Barone, Giampaolo; Casini, Angela
• Is Part Of: Chemical communications. Volume 54:Issue 6(2018)
• Page Start: 611
• Page End: 614
• Publication Date: 2018-01-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc08406d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Insights into gold finger formation by organometallics and implications for targeting pharmacologically relevant zinc-finger proteins. Abstract : The binding of Au(iii ) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was exposed to two types of zinc fingers. Notably, the cyclometallated Au-C^N complex was identified as the most selective candidate to disrupt the PARP-1 zinc finger domain, forming distinct adducts compared to the coordination compound Auphen.