An automated and robust image processing algorithm for glaucoma diagnosis from fundus images using novel blood vessel tracking and bend point detection. (February 2018)

• Record Type: Journal Article
• Authors: M., Soorya; Issac, Ashish; Dutta, Malay Kishore
• Is Part Of: International journal of medical informatics. Volume 110(2018)
• Page Start: 52
• Page End: 70
• Publication Date: 2018-02
• Subjects: Glaucoma -- Retinal image processing -- Mathematical morphology -- Optic disc -- Optic cup -- Vessel tracking; Medical informatics -- Periodicals; Information science -- Periodicals; Computers -- Periodicals; Medical technology -- Periodicals; Medical Informatics -- Periodicals; Technology, Medical -- Periodicals; Computers; Information science; Medical informatics; Medical technology; Electronic journals; Periodicals; Electronic journals; 610.285
• DOI: 10.1016/j.ijmedinf.2017.11.015
• Languages: English
• ISSNs: 1386-5056

Abstract

Highlights: Use of geometrical features makes segmentation algorithm invariant to noise. Use of bend points to determine the optic cup boundary. An inverted Gaussian-profile is used to find extreme points across vessel width. A macro-averaged f-score of 0.9485 and accuracy of 97.01% is achieved using proposed method. The proposed method is clinically significant and can work in a real time. Abstract: Glaucoma is an ocular disease which can cause irreversible blindness. The disease is currently identified using specialized equipment operated by optometrists manually. The proposed work aims to provide an efficient imaging solution which can help in automating the process of Glaucoma diagnosis using computer vision techniques from digital fundus images. The proposed method segments the optic disc using a geometrical feature based strategic framework which improves the detection accuracy and makes the algorithm invariant to illumination and noise. Corner thresholding and point contour joining based novel methods are proposed to construct smooth contours of Optic Disc. Based on a clinical approach as used by ophthalmologist, the proposed algorithm tracks blood vessels inside the disc region and identifies the points at which first vessel bend from the optic disc boundary and connects them to obtain the contours of Optic Cup. The proposed method has been compared with the ground truth marked by the medical experts and the similarity parameters, used to determine the performance of the proposed method, have yield a high similarity of segmentation. The proposed method has achieved a macro-averaged f-score of 0.9485 and accuracy of 97.01% in correctly classifying fundus images. The proposed method is clinically significant and can be used for Glaucoma screening over a large population which will work in a real time.