Focal segmental glomerular sclerosis recurrence with massive proteinuria and anuria immediately after kidney transplantation. (July 2015)

• Record Type: Journal Article
• Authors: Maruyama, Michihiro; Kitamura, Hiroshi; Akutsu, Naotake; Otsuki, Kazunori; Hasegawa, Masayuki; Aoyama, Hiromichi; Matsumoto, Ikuko; Saigo, Kenichi; Asano, Takehide
• Is Part Of: Nephrology. Volume 20(2015)Supplement 2
• Page Start: 93
• Page End: 95
• Publication Date: 2015-07
• Subjects: Focal segmental glomerular sclerosis -- Plasmapheresis -- Post‐transplant recurrence -- Rituximab; Nephrology -- Periodicals; Kidneys -- Diseases -- Periodicals; Nephrologists -- Periodicals; 616.61; 616.61
• DOI: 10.1111/nep.12455
• Languages: English
• ISSNs: 1320-5358

Abstract

Abstract: Here, we report a case of focal segmental glomerular sclerosis (FSGS) recurrence immediately (47 minutes) after transplantation. A 1‐hour biopsy specimen showed large periodic acid‐Schiff–positive granules within the cells of the swollen proximal tubule, while electron microscopy revealed podocyte swelling and partial foot process effacement. These findings were worse on day 2 biopsy. Massive proteinuria and anuria were then observed. Two courses (2 × 2 times) of plasmapheresis and rituximab were administered, and the graft function gradually recovered. A day 22 biopsy specimen showed improvement in findings compared to those observed on day 2. One year after transplantation, no signs of FSGS recurrence are evident, and graft function remains good.