Biopsy findings on a stable recipient after secondary donor specific antibody (DSA) positive and ABO incompatible kidney transplantation. (July 2015)

• Record Type: Journal Article
• Authors: Sugitani, Atsushi; Takahashi, Chihiro; Naka, Takuji; Hisamitsu, Kazunori; Yamamoto, Osamu; Kobayashi, Naoto; Kimura, Mari; Yoshida, Haruhiko; Hanaki, Takehiko; Hamazoe, Ryuichi
• Is Part Of: Nephrology. Volume 20(2015)Supplement 2
• Page Start: 79
• Page End: 80
• Publication Date: 2015-07
• Subjects: ABO incompatible transplantation -- kidney transplantation -- positive crossmatch -- protocol biopsy; Nephrology -- Periodicals; Kidneys -- Diseases -- Periodicals; Nephrologists -- Periodicals; 616.61; 616.61
• DOI: 10.1111/nep.12452
• Languages: English
• ISSNs: 1320-5358

Abstract

Abstract: Using desensitization protocol, we performed a secondary donor specific antibody (DSA) positive and ABO incompatible kidney transplantation. One‐hour biopsy showed no C4d deposition. The protocol biopsy after 2 weeks showed diffuse C4d deposition with peritubulitis. After 12 weeks, however, the protocol biopsy showed disappearance of tubulitis in spite of remaining C4d deposition. The recipient was in stable condition with excellent graft function despite high titer of the DSA. Monitoring of protocol biopsy is critical while antibody titer and the interpretation of the histological findings correlating with clinical markers must be considered.