Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex. (January 2018)

• Record Type: Journal Article
• Authors: Ueno, Hiroshi; Takao, Keizo; Suemitsu, Shunsuke; Murakami, Shinji; Kitamura, Naoya; Wani, Kenta; Okamoto, Motoi; Aoki, Shozo; Ishihara, Takeshi
• Is Part Of: Neurochemistry international. Volume 112(2017)
• Page Start: 59
• Page End: 70
• Publication Date: 2018-01
• Subjects: Aging -- Cerebral cortex -- Mouse -- Parvalbumin -- Perineuronal nets; FrA frontal association cortex -- DLO dorsolateral orbital cortex -- LO lateral orbital cortex -- VO ventral orbital cortex -- Cg cingulate cortex -- PL prelimbic cortex -- IL infralimbic cortex -- DP dorsal peduncular cortex -- M1 primary motor cortex -- M2 secondary motor cortex -- MPtA medial parietal association cortex -- LPtA lateral parietal association cortex -- PTPR parietal cortex, post, rostral -- S1Tr primary somatosensory cortex–trunk region -- S1BF primary somatosensory cortex–barrel field -- S2 secondary somatosensory cortex -- V2MM secondary visual cortex–mediomedial area -- V2ML secondary visual cortex, mediolateral area -- V1M primary visual cortex, monocular area -- V1B primary visual cortex, binocular area -- V2L secondary visual cortex, lateral area -- Au1 primary auditory cortex -- AuD secondary auditory cortex, dorsal area -- AuV secondary auditory cortex, ventral area -- TeA temporal association cortex -- Ect ectorhinal cortex -- PRh perirhinal cortex -- DIEnt dorsintermed entorhinal cortex -- DLEnt dorsolateral entorhinal cortex -- RSD retrosplenial dysgranular cortex -- RSGc retrosplenial granular cortex, c region -- RSGb etrosplenial granular cortex, b region -- RSGa retrosplenial granular cortex, a region -- AD Alzheimer's Disease; Neurochemistry -- Periodicals; Neurochemistry -- Periodicals; Neurochimie -- Périodiques; Neurochemistry; Periodicals; 612.804205
• DOI: 10.1016/j.neuint.2017.11.001
• Languages: English
• ISSNs: 0197-0186

Abstract

Abstract: Cognitive function declines with age. Such function depends on γ-oscillation in the frontal cortex. Pyramidal neurons, and the parvalbumin-expressing interneurons (PV neurons) that control them, are important for the generation of γ-oscillation. The mechanism by which cognitive function declines is unclear. Perineuronal nets (PNNs) mainly surround the soma and proximal dendrites and axon segments of PV neurons in the cerebral cortex. Previous evidence indicates that PNNs inhibit neural plasticity. If this is true, an increase in the number of neurons surrounded by PNNs or in the thickness or density of the PNNs around neurons could decrease plasticity in the cortex. To determine if an aging-related change in cortical PNNs occurs, we examined the influence of aging on PV neurons and whether Wisteria floribunda agglutinin-positive PNNs differ depending on the cortical area. The results showed that the number of PV neurons/mm 2 did not change in many areas of the cortex as mice aged. In contrast, the number of neurons in the sensory cortex surrounded by PNNs increased as mice aged. Thus, with age, PNN density increases in some cortical areas but not in others. In addition, the expression level of PV protein in PV neurons decreased with aging in the whole cortex. We suggest that decreased expression of PV protein impairs fast spiking in PV neurons. We propose that PNNs surround more neurons as age increases. This aging-related increase in PNNs decreases plasticity in the cerebral cortex and reduces cognitive function. The first step in investigating this proposal would be to determine if PNN density increases with age. Highlights: PV neuron density remained unchanged with aging in numerous cortical areas. WFA-positive PNN density increased with aging in the sensory cortex. The expression level of PV protein in PV neurons decreased with aging. The PV soma area was reduced with aging in numerous cortical areas.