The influence of rapid growth on sodium salicylate pharmacokinetics in male turkeys. Issue 1 (29th June 2017)

• Record Type: Journal Article
• Authors: Poźniak, B.; Motykiewicz‐Pers, K.; Grabowski, T.; Świtała, M.
• Is Part Of: Journal of veterinary pharmacology and therapeutics. Volume 41:Issue 1(2018)
• Page Start: 163
• Page End: 165
• Publication Date: 2017-06-29
• Subjects: age -- growth -- pharmacokinetics -- sodium salicylate -- turkeys; Veterinary pharmacology -- Periodicals; Therapeutics -- Periodicals; 636.0895105
• DOI: 10.1111/jvp.12430
• Languages: English
• ISSNs: 0140-7783

Abstract

Abstract : The aim of this study was to assess the influence of growth on the pharmacokinetics of sodium salicylate (SS) in male turkeys. SS was administered intravenously at a dose of 50 mg/kg. Plasma drug concentrations were assessed by high‐performance liquid chromatography, and pharmacokinetic parameters were calculated by noncompartmental analysis. As the age increased from 6 to 13 weeks (body weight increase from 2.35 to 9.43 kg), median body clearance decreased from 1.34 to 0.87 ml/min/kg. This caused a significant increase in the median mean residence time from 3.42 to 4.44 hr. Elimination phase proved to be biphasic and two elimination half‐lives ( T 1/2el ) were distinguished. Whereas T 1/2el1 was found to increase with age by 128%, T 1/2el2 represented a later but faster and less age‐dependent phase of elimination (increase by 56% in the respective groups). Volume of distribution decreased with age. These effects may lead to different therapeutic response to SS in turkeys of different age and body weights.