Preservation of Nuclear Spin Order by Precipitation. Issue 1 (27th November 2017)

• Record Type: Journal Article
• Authors: Eills, James; Alonso‐Valdesueiro, Javier; Salazar Marcano, David E.; Ferreira da Silva, Jesse; Alom, Shamim; Rees, Gregory J.; Hanna, John V.; Carravetta, Marina; Levitt, Malcolm H.
• Is Part Of: Chemphyschem. Volume 19:Issue 1(2018)
• Page Start: 40
• Page End: 44
• Publication Date: 2017-11-27
• Subjects: EPR spectroscopy -- NMR spectroscopy -- precipitation -- relaxation -- spin diffusion; Chemistry, Physical and theoretical -- Periodicals; 541.05
• DOI: 10.1002/cphc.201701189
• Languages: English
• ISSNs: 1439-4235

Abstract

Abstract: We demonstrate that non‐equilibrium nuclear spin order survives precipitation from solution and redissolution. The effect is demonstrated on 13 C‐ and 2 H‐labeled sodium fumarate, with precipitation and dissolution achieved by altering the pH. The lifetime of the spin magnetization in the precipitate suspension is found to be much longer than in solution. Our preliminary results show an extension of the effective relaxation time T1 for the metabolite fumarate by a factor of ≈6. We show that when the free radical agent TEMPO is present in the solution, it is not incorporated into the precipitate, suggesting that this procedure may provide a means to store and transport agents polarized by dynamic nuclear polarization. Although the relaxation time, T1, of the precipitate suspension is longer than that of the same molecules in solution, it is significantly shorter than that observed in the immobilized solid state. Abstract : Keep the spin ! Non‐equilibrium spin order is demonstrated to survive precipitation from solution and redissolution. This approach may be useful for preserving substances in a state of non‐equilibrium nuclear spin order, as generated by hyperpolarization techniques such as dynamic nuclear polarization.