Improved Free‐Energy Landscape Quantification Illustrated with a Computationally Designed Protein–Ligand Interaction. Issue 1 (28th December 2017)

• Record Type: Journal Article
• Authors: Van Patten, William J.; Walder, Robert; Adhikari, Ayush; Okoniewski, Stephen R.; Ravichandran, Rashmi; Tinberg, Christine E.; Baker, David; Perkins, Thomas T.
• Is Part Of: Chemphyschem. Volume 19:Issue 1(2018)
• Page Start: 5
• Page End: 5
• Publication Date: 2017-12-28
• Subjects: Chemistry, Physical and theoretical -- Periodicals; 541.05
• DOI: 10.1002/cphc.201701340
• Languages: English
• ISSNs: 1439-4235

Abstract

Abstract: The front cover artwork is provided by the groups of David Baker (Univ. of Washington and HHMI) and Thomas Perkins (JILA, NIST and Univ. of Colorado). The image shows an AFM cantilever pulling on a computationally designed protein bound to digoxigenin attached to the end of a short DNA molecule with a conceptual free‐energy landscape as background. Read the full text of the article at10.1002/cphc.201701147 . Abstract : "Quantifying the energy landscape underlying protein–ligand interactions leads to an enhanced understanding of molecular recognition. Here, we introduce an enhanced AFM assay and apply it to probe the computationally designed protein DIG10.3 binding to its target ligand, digoxigenin…" This and more about the story behind the front cover can be found in the Communication at10.1002/cphc.201701147 .