Front Cover: Improved Free‐Energy Landscape Quantification Illustrated with a Computationally Designed Protein–Ligand Interaction (ChemPhysChem 1/2018). Issue 1 (29th December 2017)

• Record Type: Journal Article
• Authors: Van Patten, William J.; Walder, Robert; Adhikari, Ayush; Okoniewski, Stephen R.; Ravichandran, Rashmi; Tinberg, Christine E.; Baker, David; Perkins, Thomas T.
• Is Part Of: Chemphyschem. Volume 19:Issue 1(2018)
• Page Start: 1
• Page End: 1
• Publication Date: 2017-12-29
• Subjects: atomic force microscopy -- energy landscape -- protein design -- protein–ligand interactions -- single-molecule force spectroscopy; Chemistry, Physical and theoretical -- Periodicals; 541.05
• DOI: 10.1002/cphc.201701341
• Languages: English
• ISSNs: 1439-4235

Abstract

Abstract : The Front Cover visualizes the concept of using single‐molecule force spectroscopy based on atomic force microscopy to better quantify the energy landscape underlying protein–ligand interactions. We introduce an enhanced AFM assay and apply it to probe the binding of a computationally designed protein to its target ligand. More information can be found in the Communication by W. J. Van Patten et al. onpage 19 in Issue 1, 2018 (DOI:10.1002/cphc.201701147 ).