Analysis of clinical features and pathology of serum HBsAg positive glomerulonephritis. Issue 3 (8th November 2017)

• Record Type: Journal Article
• Authors: Peng, Tao; Xie, Tingting; Liu, Lei; Zhen, Junhui; Yang, Xiangdong
• Is Part Of: Journal of medical virology. Volume 90:Issue 3(2018)
• Page Start: 612
• Page End: 615
• Publication Date: 2017-11-08
• Subjects: clinical and pathological analysis -- glomerulonephritis -- HBsAg‐positive; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.24959
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract : To analyze the relationship between the factors related to the occurrence of HBV‐GN and serum HBsAg‐positive glomerulonephritis. A total of 56 patients were enrolled in the present study. All enrolled cases were divided into two groups according to whether HBsAg and/or HBcAg was present in renal kidney tissue: patients with Hepatitis B virus‐associated nephritis (HBV‐GN group, 30 cases) and patients with hepatitis B virus‐combined nephritis (HBV‐CG group, 26 cases). We sought to analyze the differences in clinical features and pathological characteristics in both groups. The rate of HBeAg positivity in the HBV‐GN group was considerably increased in the HBV‐CG group ( P < 0.05), and the number of patients with HBsAg+HBeAg+HBcAb+ in the HBV‐GN group was considerably increased in the HBV‐CG group (21 cases vs 10 cases) ( P < 0.05). Moreover, the number of MCD patients diagnosed by renal biopsy in the HBV‐GN group was reduced compared with the HBV‐CG group (1 case vs 7 cases) ( P < 0.05). HBV infection and high‐virus proliferation status were closely related with HBV‐GN.