Genotypes of human metapneumovirus circulating during 2010‐2012 in children from Panama. Issue 3 (1st November 2017)

• Record Type: Journal Article
• Authors: Ábrego, Leyda E.; Mirazo, Santiago; Delfraro, Adriana; Franco, Danilo; Castillo, Marlene; Gaitán, Melissa; Castillo, Juan; Moreno, Brechla; Pascale, Juan M.; Arbiza, Juan
• Is Part Of: Journal of medical virology. Volume 90:Issue 3(2018)
• Page Start: 604
• Page End: 608
• Publication Date: 2017-11-01
• Subjects: acute respiratory infections (ARI) -- genotype -- human metapneumovirus -- nucleoprotein; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.24969
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract : Human metapneumovirus (HMPV) is a common causative agent of severe respiratory tract infections in children under 5 years old, the elderly and immunocompromised patients, being responsible for 5‐15% of all viral respiratory infections requiring hospitalization. Though HMPV was included in the surveillance program for respiratory viruses in 2010, its genotype distribution remains unknown. Herein, 45 positive samples to HMPV from children ≤5 years old were characterized by phylogenetic analysis based on N gene sequence. Results showed the co‐circulation of four sub‐lineages: A2a (8.8%), A2b (55.5%), B1 (15.6%), and B2 (20%), demonstrating the genetic heterogeneity of HMPV circulating in Panamá.