In vivo proton observed carbon edited (POCE) 13C magnetic resonance spectroscopy of the rat brain using a volumetric transmitter and receive‐only surface coil on the proton channel. Issue 2 (12th May 2017)

• Record Type: Journal Article
• Authors: Kumaragamage, Chathura; Madularu, Dan; Mathieu, Axel P.; De Feyter, Henk; Rajah, M. Natasha; Near, Jamie
• Is Part Of: Magnetic resonance in medicine. Volume 79:Issue 2(2018)
• Page Start: 628
• Page End: 635
• Publication Date: 2017-05-12
• Subjects: 1H‐[13C] MRS -- short TE -- POCE -- localized 13C edited MRS -- [1‐13C] glucose infusion -- PRESS‐POCE; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.26751
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: In vivo carbon‐13 ( 13 C) MR spectroscopy (MRS) is capable of measuring energy metabolism and neuroenergetics, noninvasively in the brain. Indirect ( 1 H‐[ 13 C]) MRS provides sensitivity benefits compared with direct 13 C methods, and normally includes a 1 H surface coil for both localization and signal reception. The aim was to develop a coil platform with homogenous B 1 + and use short conventional pulses for short echo time proton observed carbon edited (POCE) MRS. Methods: A 1 H‐[ 13 C] MRS coil platform was designed with a volumetric resonator for 1 H transmit, and surface coils for 1 H reception and 13 C transmission. The Rx‐only 1 H surface coil nullifies the requirement for a T/R switch before the 1 H preamplifier; the highpass filter and preamplifier can be placed proximal to the coil, thus minimizing sensitivity losses inherent with POCE‐MRS systems described in the literature. The coil platform was evaluated with a PRESS‐POCE sequence (TE = 12.6 ms) on a rat model. Results: The coil provided excellent localization, uniform spin nutation, and sensitivity. 13 C labeling of Glu‐H4 and Glx‐H3 peaks, and the Glx‐H2 peaks were observed approximately 13 and 21 min following the infusion of 1‐ 13 C glucose, respectively. Conclusion: A convenient and sensitive platform to study energy metabolism and neurotransmitter cycling is presented. Magn Reson Med 79:628–635, 2018. © 2017 International Society for Magnetic Resonance in Medicine.