Different EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report. Issue 1 (1st November 2017)

• Record Type: Journal Article
• Authors: Sakai, Hiroki; Saji, Hisashi; Kimura, Hiroyuki; Tsuda, Masataka; Wakiyama, Yoichi; Miyazawa, Tomoyuki; Marushima, Hideki; Kojima, Koji; Hoshikawa, Masahiro; Takagi, Masayuki; Nakamura, Haruhiko
• Is Part Of: Thoracic cancer. Volume 9:Issue 1(2018)
• Page Start: 189
• Page End: 192
• Publication Date: 2017-11-01
• Subjects: EGFR mutation -- multiple lung cancer -- synchronous lung cancer; Chest -- Cancer -- Periodicals; Chest -- Cancer -- Treatment -- Periodicals; Chest -- Surgery -- Periodicals; 616.99494005
• DOI: 10.1111/1759-7714.12554
• Languages: English
• ISSNs: 1759-7706

Abstract

Abstract : Routine clinical and pathological evaluations to determine the relationship between different lesions are often not completely conclusive. Interestingly, detailed genetic analysis of tumor samples may provide important additional information and identify second primary lung cancers. In the present study, we report cases of two synchronous lung adenocarcinomas composed of two distinct pathological subtypes with different EGFR gene mutations: a homozygous deletion in exon 19 of the papillary adenocarcinoma subtype and a point mutation of L858R in exon 21 of the tubular adenocarcinoma. The present report highlights the clinical importance of molecular cancer biomarkers to guide management decisions in cases involving multiple lung tumors.