Early development of immune reconstitution inflammatory syndrome related to Pneumocystis pneumonia after antiretroviral therapy. (April 2014)

• Record Type: Journal Article
• Authors: Mok, Hoi Ping; Hart, Elizabeth; Venkatesan, Pradhib
• Is Part Of: International journal of STD & AIDS. Volume 25:Number 5(2014:May)
• Page Start: 373
• Page End: 377
• Publication Date: 2014-04
• Subjects: HIV -- AIDS -- Pneumocystis pneumonia -- Pneumocystis jirovecii -- immune reconstitution inflammatory syndrome -- IRIS -- antiretroviral therapy; Sexually transmitted diseases -- Periodicals; AIDS (Disease) -- Periodicals; 616.951
• DOI: 10.1177/0956462413506888
• Languages: English
• ISSNs: 0956-4624

Abstract

Immune reconstitution inflammatory syndrome is a recognized complication after the initiation of combination antiretroviral therapy (cART). We report a patient who developed life-threatening pulmonary immune reconstitution inflammatory syndrome (IRIS) three days after initiation of cART. We reviewed published cases of IRIS after Pneumocystis pneumonia (PCP), in particular the time from initiation of cART to IRIS event. The median duration from the initiation of cART to the onset of IRIS was 15 days in the 33 patients reviewed. This report alerts clinicians to the rapidity of the development of pulmonary IRIS following PCP after the initiation of cART.