Individual and partner risk factors associated with abnormal cervical cytology among women in HIV-discordant relationships. (April 2014)

• Record Type: Journal Article
• Authors: Soh, Jason; Rositch, Anne F; Koutsky, Laura; Guthrie, Brandon L; Choi, Robert Y; Bosire, Rose K; Gatuguta, Ann; Smith, Jennifer S; Kiarie, James; Lohman-Payne, Barbara; Farquhar, Carey
• Is Part Of: International journal of STD & AIDS. Volume 25:Number 5(2014:May)
• Page Start: 315
• Page End: 324
• Publication Date: 2014-04
• Subjects: HIV -- AIDS -- sexually transmitted infection -- human papillomavirus -- HPV -- cervical cancer -- cervical intraepithelial neoplasia -- cytology -- discordant couples -- Africa; Sexually transmitted diseases -- Periodicals; AIDS (Disease) -- Periodicals; 616.951
• DOI: 10.1177/0956462413504554
• Languages: English
• ISSNs: 0956-4624

Abstract

Individual and sexual partner characteristics may increase the risk of abnormal cervical cytology among women in human immunodeficiency virus (HIV)-discordant relationships. Papanicolaou smears were obtained in a prospective cohort of Kenyan HIV-discordant couples. Of 441 women, 283 (64%) were HIV-infected and 158 (36%) were HIV-uninfected with HIV-infected partners. Overall, 79 (18%) had low-grade and 25 (6%) high-grade cervical abnormalities. Male herpes simplex virus type 2 (HSV-2) seropositivity and lower couple socioeconomic status were associated with cervical abnormalities ( p < 0.05). HIV-uninfected women with HIV-infected male sex partners (CD4 > 350 cells/µL) had the lowest prevalence of high-grade cervical lesions. HIV-infected women (CD4 > 350 cells/µL) and HIV-uninfected women with HIV-infected partners (CD4 ≤ 350 cells/µL) were at similar intermediate risk ( p > 0.05), and HIV-infected women (CD4 ≤ 350 cells/µL) had significantly higher risk of high-grade cervical abnormalities ( p = 0.05). Women in HIV-discordant relationships have high rates of cervical lesions and this may be influenced by couple-level factors, including HIV status and CD4 count of the infected partner.