The Next Step Forward in Ubiquitin-Specific Protease 7 Selective Inhibition. Issue 12 (21st December 2017)

• Record Type: Journal Article
• Authors: Desroses, Matthieu; Altun, Mikael
• Is Part Of: Cell chemical biology. Volume 24:Issue 12(2017)
• Page Start: 1429
• Page End: 1431
• Publication Date: 2017-12-21
• Subjects: Biochemistry -- Periodicals; 572.05
• DOI: 10.1016/j.chembiol.2017.12.003
• Languages: English
• ISSNs: 2451-9456

Abstract

Abstract : Ubiquitin-specific protease 7 is a validated anticancer target; thus, selective USP7 inhibitors are of great interest. In this issue of Cell Chemical Biology, Lamberto et al. (2017) andPozhidaeva et al. (2017) report important insights into the structural inhibitor-enzyme interplay, lighting the way toward the development of selective inhibitors. Abstract : Ubiquitin-specific protease 7 is a validated anticancer target; thus, selective USP7 inhibitors are of great interest. In this issue of Cell Chemical Biology, Lamberto et al. (2017) and Pozhidaeva et al. (2017) report important insights into the structural inhibitor-enzyme interplay, lighting the way toward the development of selective inhibitors.