Ciprofloxacin‐induced immune‐mediated thrombocytopenia: No cross‐reactivity with gemifloxacin. (8th August 2017)

• Record Type: Journal Article
• Authors: Sim, D. W.; Yu, J. E.; Jeong, J.; Koh, Y.‐I.
• Is Part Of: Journal of clinical pharmacy and therapeutics. Volume 43:Number 1(2018)
• Page Start: 134
• Page End: 136
• Publication Date: 2017-08-08
• Subjects: ciprofloxacin -- cross‐reactivity -- drug‐induced immune thrombocytopenia -- gemifloxacin; Clinical pharmacology -- Periodicals; Chemotherapy -- Periodicals; 615
• DOI: 10.1111/jcpt.12596
• Languages: English
• ISSNs: 0269-4727

Abstract

Summary: What is known and objective: Fluoroquinolone‐induced immune‐mediated thrombocytopenia is uncommon, and no reports of cross‐reactivity among fluoroquinolones exist. Here, we describe a case of ciprofloxacin‐induced immune thrombocytopenia with no cross‐reactivity with gemifloxacin. Case description: A 77‐year‐old woman showed profound thrombocytopenia immediately after two ciprofloxacin injections for pneumonia. Platelet counts recovered rapidly after ciprofloxacin discontinuation. She had experienced thrombocytopenia after ciprofloxacin administration 4 years earlier, which was assumed to be ciprofloxacin‐induced immune‐related. Interestingly, no thrombocytopenia occurred following the subsequent exposure to another fluoroquinolone, gemifloxacin. What is new and conclusion: No cross‐reactivity occurred between ciprofloxacin and gemifloxacin in this fluoroquinolone‐induced immune thrombocytopenia case. Abstract : Changes in blood platelet count following administration of various antibiotics during admission.