Overview of small bowel angioectasias: clinical presentation and treatment options. (1st February 2018)

• Record Type: Journal Article
• Authors: Chetcuti Zammit, Stefania; Koulaouzidis, Anastasios; Sanders, David S.; McAlindon, Mark E.; Rondonotti, Emanuele; Yung, Diana E.; Sidhu, Reena
• Is Part Of: Expert review of gastroenterology & hepatology. Volume 12:Number 2(2018)
• Page Start: 125
• Page End: 139
• Publication Date: 2018-02-01
• Subjects: Argon plasma coagulation -- capsule endoscopy -- double balloon enteroscopy -- serum biomarkers -- small bowel angioectasias -- somatostatin analogues -- thalidomide; Gastroenterology -- Periodicals; Liver -- Diseases -- Periodicals; 616.3
• DOI: 10.1080/17474124.2018.1390429
• Languages: English
• ISSNs: 1747-4124

Abstract

ABSTRACT: Introduction : Elderly patients with multiple co-morbidities are at an increased risk of developing small bowel angioectasias. Treating these lesions can be both challenging and costly with patients requiring extensive investigations and recurrent admissions for iron infusions and blood transfusions as well as invasive procedures. This review presents treatment options and describes in detail drugs that should be considered whilst taking into account their effectiveness and their safety profile. Areas covered : A PubMed search was carried out using the following keywords: small bowel angiodysplasias, small bowel angioectasias, small bowel bleeding and obscure gastrointestinal bleeding to assess existing evidence. The pathophysiology and risk factors are covered in this review together with appropriate methods of investigation and management. Treatment options discussed are endoscopic measures, surgical options and pharmacotherapy. The role of serum biomarkers is also discussed. Expert commentary : Future work should be directed at alternative drugs with a good safety profile that target biomarkers. Novel pharmacotherapy directed at biomarkers could potentially provide a non-invasive treatment option for angioectasias particularly in the elderly where management can be challenging.