Cadmium nitrate-induced cytotoxicity and genotoxicity via caspases in Neuro-2A neurons. (2nd January 2018)

• Record Type: Journal Article
• Authors: Wang, Chuan-Cheng; Yang, Ming-Ling; Yang, Ching-Ping; Liang, Ching-Hui; Lee, Chien-Ying; Lin, Hui-Wei; Kuan, Yu-Hsiang
• Is Part Of: Toxin reviews. Volume 37:Number 1(2018)
• Page Start: 39
• Page End: 43
• Publication Date: 2018-01-02
• Subjects: Cd(NO3)2 -- N2a neurons -- cytotoxicity -- genotoxicity -- caspases; Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.1080/15569543.2017.1313276
• Languages: English
• ISSNs: 1556-9543

Abstract

Abstract: Major source for human exposure to cadmium nitrate (Cd(NO3 )2 ) is from smoking and occupational hazard. Cd(NO3 )2 -induced neurotoxicity and related mechanism in neurons are still unknown. Here, Cd(NO3 )2 induced cytotoxicity in a concentration- and time-dependent manners on Neuro-2A (N2A) neurons. Genotoxicity, which included micronucleus formation and DNA damage, and caspases, which included caspase-3, -8 and -9, activities were increased by Cd(NO3 )2 in a concentration-dependent manner. The concentration trends of Cd(NO3 )2 : 1, 3 and 10 μM, were similar in the significant induction of cytotoxicity and genotoxicity and the up-regulation of the activities of caspase-3, -8, -9. In conclusion, cytotoxicity and genotoxicity were induced by Cd(NO3 )2 via caspases activities on neurons.