Effect of volume of porogens on the porosity of PLGA scaffolds in pH-controlled environment. (7th February 2018)

• Record Type: Journal Article
• Authors: Gupta, Manish; Aina, Adeyinka; Boukari, Yamina; Doughty, Stephen; Morris, Andrew; Billa, Nashiru
• Is Part Of: Pharmaceutical development and technology. Volume 23:Number 2(2018)
• Page Start: 207
• Page End: 210
• Publication Date: 2018-02-07
• Subjects: Porosity -- PLGA -- scaffolds -- tissue regeneration and porogens; Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.1080/10837450.2017.1304415
• Languages: English
• ISSNs: 1083-7450

Abstract

Abstract: Poly(lactic-co-glycolic acid) (PLGA) is a well-studied biodegradable polymer used in drug delivery and other medical applications such as in tissue regeneration. It is often necessary to impart porosity within the scaffold (microparticles) in order to promote the growth of tissue during the regeneration process. Sodium chloride and ammonium bicarbonate have been extensively used as porogens in the generation of porous microstructure. In this study, we compared the effect of volumes (250 μl, 500 μl and 750 μl) of two porogens, sodium chloride (1.71 M) and ammonium bicarbonate (1.71 M), on the porosity of PLGA microparticles.