Allergic Conjunctivitis and the Associated Risk of Migraine Among Children: A Nationwide Population-based Cohort Study. (2nd November 2017)

• Record Type: Journal Article
• Authors: Wang, I-Chung; Tsai, Jeng-Dau; Shen, Te-Chun; Lin, Cheng-Li; Li, Tsai-Chung; Wei, Chang-Ching
• Is Part Of: Ocular immunology and inflammation. Volume 25:Number 6(2017)
• Page Start: 802
• Page End: 810
• Publication Date: 2017-11-02
• Subjects: Allergic conjunctivitis -- children -- cohort study -- migraine; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2016.1178303
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To investigate the risk of migraine in children with allergic conjunctivitis (AC). Methods : In this population-based cohort study, 309 138 children with AC and 309 138 non-AC controls were included between 2000 and 2007. By 2008 end, the incidences of migraine in both cohorts, and the AC-to-non-AC cohort hazard ratios (HRs) were measured. Results : The incidence of migraine during the study period was 1.92-fold higher in the AC cohort than in the non-AC cohort. The risk was greater for boys with AC and children aged <6 years. The mean time-interval between physician-diagnosed AC to physician-diagnosed migraine was 3.67 years (SD = 2.19).The risk of migraine development in the AC cohort increased with follow-up time and was highest during 4–5 years after AC diagnosis. The children with AC more likely had migraine without than with aura. Conclusions : Children with AC had a higher incidence and subsequent risk of migraine.