Effects of resveratrol on high-fructose-induced testis injury in rats. (2nd January 2018)

• Record Type: Journal Article
• Authors: Meydanli, Elif Guzel; Gumusel, Asli; Ozkan, Serbay; Tanriverdi, Gamze; Balci, M. B. Can; Develi Is, Seval; Hazar, A. Ismet; Uysal, Mujdat; Bekpinar, Seldag
• Is Part Of: Ultrastructural pathology. Volume 42:Number 1(2018)
• Page Start: 65
• Page End: 73
• Publication Date: 2018-01-02
• Subjects: Apoptosis -- electron microscopy -- high-fructose diet -- resveratrol -- testis; Pathology, Cellular -- Periodicals; Ultrastructure (Biology) -- Periodicals; Diagnosis, Electron microscopic -- Periodicals; Microscopy, Electron; Pathology; 616.07582
• DOI: 10.1080/01913123.2017.1397075
• Languages: English
• ISSNs: 0191-3123

Abstract

ABSTRACT: This study investigated whether a high-fructose (HFr) diet changes the morphology of seminiferous tubules (ST) in rats and resveratrol (RES) has a possible restoring effect in this sense. Fructose (30%; w/v) was administered to rats alone or together with RES (50 mg/L) in drinking water for 8 weeks. In the HFr group, destruction of the germinal epithelium led to the detection of immature germ cells in the lumen. HFr diet gave rise to a decrease in the ST diameters ( p < 0.05), Johnsen's tubular biopsy score values ( p < 0.001), and an increase in the apoptotic index ( p < 0.05). Ultrastructurally, HFr feeding increased lipid accumulation ( p < 0.01), mitochondrial damage, and acrosomal abnormalities in spermatogenic cells. Treatment of HFr -fed rats with RES improved the reduced ST diameters and overall general histological and ultrastructural abnormalities of the STs, but did not change the increased apoptotic index.