A nickel catalyzed acceptorless dehydrogenative approach to quinolines. Issue 2 (15th December 2017)

• Record Type: Journal Article
• Authors: Parua, Seuli; Sikari, Rina; Sinha, Suman; Das, Siuli; Chakraborty, Gargi; Paul, Nanda D.
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 2(2017)
• Page Start: 274
• Page End: 284
• Publication Date: 2017-12-15
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob02670f
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A general, efficient and environmentally benign, one-step synthesis of substituted quinoline derivatives was achieved by acceptorless dehydrogenative coupling of o -aminobenzylalcohols with ketones and secondary alcohols catalyzed by a cheap, earth abundant and easy to prepare macrocyclic nickel catalyst [Ni(MeTAA)]. Abstract : A general, efficient and environmentally benign, one-step synthesis of substituted quinoline derivatives was achieved by acceptorless dehydrogenative coupling of o -aminobenzylalcohols with ketones and secondary alcohols catalyzed by a cheap, earth abundant and easy to prepare nickel catalyst [Ni(MeTAA)], featuring a tetraaza macrocyclic ligand (tetramethyltetraaza[14]annulene (MeTAA)). A wide variety of substituted quinolines were synthesized in high yields starting from readily available o -aminobenzylalcohols and ketones or secondary alcohols. A few controlled reactions were carried out to establish the acceptorless dehydrogenative nature of the reactions.