Subclinical cerebrovascular disease in NAFLD without overt risk factors for atherosclerosis. (January 2018)

• Record Type: Journal Article
• Authors: Airaghi, Lorena; Rango, Mario; Maira, Diletta; Barbieri, Valentina; Valenti, Luca; Lombardi, Rosa; Biondetti, Pietro; Fargion, Silvia; Fracanzani, Anna Ludovica
• Is Part Of: Atherosclerosis. Volume 268(2018)
• Page Start: 27
• Page End: 31
• Publication Date: 2018-01
• Subjects: Cerebrovascular disease -- Atherosclerosis -- Metabolic syndrome -- Non-alcoholic fatty liver disease (NAFLD) -- Cerebral blood flow -- Magnetic resonance spectroscopy (MRS); Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2017.11.012
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background and aims: Non-alcoholic fatty liver disease is recognized not only as part of the metabolic syndrome but also as an independent predictor of cardiovascular disease. Methods: In this study, NMR spectroscopy method, together with perfusion techniques, was used to detect subclinical brain vascular damage in subjects with NAFLD without overt atherosclerosis risk factors (i.e. hypertension, diabetes, hypercholesterolemia, obesity). Results: The results suggest that subjects with histologically proven NAFLD have a reduced cerebral perfusion (CBFr) confined to limited brain areas, i.e., left semioval center and posterior cingulate cortex. No statistically significant differences in CBFr values were found, dividing the NAFLD cohort into subgroups, considering NAS score, presence/absence of NASH/fibrosis, and degree of steatosis. Conclusions: Our data suggest that NAFLD per se may be involved in cerebral atherosclerotic disease. It will be interesting to draw longitudinal studies to determine whether these changes could evolve in more serious cerebral injury. Highlights: Subclinical cerebrovascular disease is present in NAFLD with no other risk factors. NAFLD could be considered as an independent predictor of cardiovascular disease. NMR spectroscopy with perfusion techniques detects very early cerebral damage.