Acid-promoted furan annulation and aromatization: An access to benzo[b]furan derivatives. Issue 4 (25th January 2018)

• Record Type: Journal Article
• Authors: Ao, Jun; Liu, Yidong; Jia, Shiqi; Xue, Lu; Li, Dongmei; Tan, Yu; Qin, Wenling; Yan, Hailong
• Is Part Of: Tetrahedron. Volume 74:Issue 4(2018)
• Page Start: 433
• Page End: 440
• Publication Date: 2018-01-25
• Subjects: Organocatalysis -- Benzo[b]furans -- Furan annulation -- Aromatization -- Polycyclic compounds; WHKGSJRBNMUKJB-NFGAQBCYSA-N -- YOESJHQULOBRPW-UHFFFAOYSA-N -- NSMKJNQBALKQSQ-UHFFFAOYSA-N -- AXEUIEJWSMFDAU-IJCUBMALSA-N -- JKMFWYSPRGVQFL-UHFFFAOYSA-N -- UQWYRHISIBGKEC-UHFFFAOYSA-N -- KTHAATPRVMAXPG-UHFFFAOYSA-N -- RCBDUHHRBFKNIE-BISPIMOYSA-Q; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2017.11.049
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: An unprecedented PTSA-promoted furan annulation and aromatization in one pot has been developed. This process offers a simple and efficient synthetic route for the construction of various highly substituted benzo[ b ]furan derivatives, which are widely used not only in drug active molecules but also organic semiconductor and organic light-emitting devices. The preliminary mechanism study indicated this transformation proceeded sequentially via furan annulation and aromatization. Graphical abstract: