Clinically isolated syndromes with no further disease activity suggestive of multiple sclerosis at the age of population life expectancy. (April 2014)

• Record Type: Journal Article
• Authors: Novakova, L; Skoog, B; Runmarker, B; Ekholm, S; Winblad, S; Lisovskaja, V; Andersen, O
• Is Part Of: Multiple sclerosis. Volume 20:Number 4(2014)
• Page Start: 496
• Page End: 500
• Publication Date: 2014-04
• Subjects: Clinically isolated syndrome -- multiple sclerosis -- cohort -- optic neuritis -- neuropsychology -- magnetic resonance imaging; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458513496345
• Languages: English
• ISSNs: 1352-4585

Abstract

The proportion of patients with clinically isolated syndrome (CIS) reported to convert to clinically definite multiple sclerosis varied between 30 and 75%. We studied the lifetime probability of remaining in the "CIS only" condition. The study was based on the longitudinally followed Gothenburg 1950–1964 incidence cohort ( n = 306). Survival analysis revealed that 17.8% of 236 attack onset patients remained "CIS only". Patients with afferent (optic and sensory) symptoms had a better prognosis with approximately 30% of these patients remaining "CIS only". Patients who had experienced no relapse during the first 25 years remained "CIS only" for the subsequent 25 years of follow-up.