YAP needs Nemo to guide a Hippo. (15th December 2016)

• Record Type: Journal Article
• Authors: Hergovich, Alexander
• Is Part Of: EMBO reports. Volume 18:Number 1(2017)
• Page Start: 3
• Page End: 4
• Publication Date: 2016-12-15
• Subjects: Molecular biology -- Periodicals; Molecular Biology -- Periodicals; Molecular biology; Periodicals; 572.8
• DOI: 10.15252/embr.201643622
• Languages: English
• ISSNs: 1469-221X

Abstract

Abstract : The Hippo growth control pathway coordinates cell proliferation, death, differentiation and stemness through regulatory phosphorylation of the YAP proto‐oncoprotein, a major nuclear effector of Hippo signalling. In particular, YAP phosphorylation on Ser127 can promote inhibitory 14‐3‐3 interactions and cytoplasmic sequestration. Two studies in this issue of EMBO Reports show that Ser128 phosphorylation of YAP by the Nemo‐like kinase (NLK) disrupts 14‐3‐3 interactions, thereby promoting nuclear accumulation of active YAP1 2 . Notably, Ser127‐phosphorylated YAP can be nuclear and co‐transcriptionally active upon osmotic stress, thus, challenging the dogma of YAP regulation by Ser127 phosphorylation. Abstract : Two studies in this issue show that Ser128 phosphorylation of the Hippo pathway protein YAP by the Nemo‐like kinase (NLK) promotes nuclear accumulation of active YAP, challenging the dogma of YAP regulation via Ser127 phosphorylation.